Clinical depression Also called: Major depression ABOUT SYMPTOMS TREATMENTS A mental health disorder characterised by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life. Treatable by a medical professional Medium-term: resolves within months Requires a medical diagnosis Lab tests or imaging rarely required Possible causes include a combination of biological, psychological and social sources of distress. Increasingly, research suggests that these factors may cause changes in brain function, including altered activity of certain neural circuits in the brain. The persistent feeling of sadness or loss of interest that characterises major depression can lead to a range of behavioural and physical symptoms. These may include changes in sleep, appetite, energy level, concentration, daily behaviour
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